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The process took a week. Giardia Research? I interviewed at Barnes Noble (Clifton, NJ). Went in for short interview with manager (about 15 minutes), relaxed and usip essay, casual, very easy process. Felt more like a chat about former jobs and what I liked and disliked about them than an interview. What was a situation at your last job that you could have handled better? Answer Question. Barnes Noble Response. Other Interview Reviews for Barnes Noble. I applied online.
I interviewed at Barnes Noble. Giardia Paper? I applied online, and got a call back after a couple of weeks. The interview was fast and easy. Two managers asked me very basic questions while I sat in the cafe on site. Barnes Noble Response. I applied online. I interviewed at Barnes Noble.
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Barnes Noble Response. I applied online. The process took 1+ week. I interviewed at Barnes Noble (Palos Park, IL) in July 2017. I submitted my application through their website on a Wednesday and got a call the the following Monday from a manager. She asked me some questions about my availability and giardia paper, why I wanted to work at BN. I scheduled an in-person interview for Thursday. Tell me about yourself.
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Riociguat for the Treatment of giardia research paper, Pulmonary Arterial Hypertension. Hossein-Ardeschir Ghofrani, M.D., Nazzareno Galie, M.D., Friedrich Grimminger, M.D., Ekkehard Grunig, M.D., Marc Humbert, M.D., Zhi-Cheng Jing, M.D., Anne M. Keogh, M.D., David Langleben, M.D., Michael Ochan Kilama, M.D., Arno Fritsch, Ph.D., Dieter Neuser, M.D., and french Lewis J. Rubin, M.D., for the PATENT-1 Study Group * N Engl J Med 2013; 369:330-340 July 25, 2013 DOI: 10.1056/NEJMoa1209655. Riociguat, a soluble guanylate cyclase stimulator, has been shown in research paper, a phase 2 trial to be beneficial in resume, the treatment of paper, pulmonary arterial hypertension. In this phase 3, double-blind study, we randomly assigned 443 patients with symptomatic pulmonary arterial hypertension to receive placebo, riociguat in individually adjusted doses of up to 2.5 mg three times daily (2.5 mg–maximum group), or riociguat in individually adjusted doses that were capped at 1.5 mg three times daily (1.5 mg–maximum group). The 1.5 mg–maximum group was included for french essay, exploratory purposes, and the data from giardia paper, that group were analyzed descriptively. Patients who were receiving no other treatment for pulmonary arterial hypertension and patients who were receiving endothelin-receptor antagonists or (nonintravenous) prostanoids were eligible. The primary end point was the change from baseline to the end of week 12 in the distance walked in 6 minutes. Secondary end points included the change in pulmonary vascular resistance, N-terminal pro–brain natriuretic peptide (NT-proBNP) levels, World Health Organization (WHO) functional class, time to timeline, clinical worsening, score on the Borg dyspnea scale, quality-of-life variables, and safety. By week 12, the research paper, 6-minute walk distance had increased by a mean of 30 m in the 2.5 mg–maximum group and had decreased by descriptive essay, a mean of 6 m in research paper, the placebo group (least-squares mean difference, 36 m; 95% confidence interval, 20 to 52; P0.001). Prespecified subgroup analyses showed that riociguat improved the french essay writing, 6-minute walk distance both in giardia research paper, patients who were receiving no other treatment for the disease and in those who were receiving endothelin-receptor antagonists or prostanoids. Halifax Ns? There were significant improvements in pulmonary vascular resistance (P0.001), NT-proBNP levels (P0.001), WHO functional class (P=0.003), time to clinical worsening (P=0.005), and Borg dyspnea score (P=0.002).
The most common serious adverse event in the placebo group and the 2.5 mg–maximum group was syncope (4% and 1%, respectively). Riociguat significantly improved exercise capacity and secondary efficacy end points in paper, patients with pulmonary arterial hypertension. (Funded by Bayer HealthCare; PATENT-1 and PATENT-2 ClinicalTrials.gov numbers, NCT00810693 and NCT00863681, respectively.) Pulmonary arterial hypertension is a life-threatening disease that is characterized by increased pulmonary vascular resistance owing to progressive vascular remodeling, which can ultimately lead to right heart failure and death. 1,2 Current treatments include phosphodiesterase type 5 inhibitors, prostanoids, and endothelin-receptor antagonists. Descriptive Essay About? 1 However, mortality remains high despite treatment, 3 and there is a considerable unmet medical need in the management of this disorder. As noted elsewhere in this issue of the Journal, 4 riociguat is a member of a novel therapeutic class known as soluble guanylate cyclase stimulators. Riociguat has a dual mode of action, acting in synergy with endogenous nitric oxide and also directly stimulating soluble guanylate cyclase independently of nitric oxide availability. 5,6 In several phase 1 and 2 clinical studies, riociguat improved hemodynamic variables and exercise capacity in patients with pulmonary arterial hypertension. 5,7 We now present the results of the phase 3 Pulmonary Arterial Hypertension Soluble Guanylate Cyclase–Stimulator Trial 1 (PATENT-1). In this study, we investigated the paper, efficacy and body essay side-effect profile of riociguat in patients with symptomatic pulmonary arterial hypertension, both those who were receiving no other treatment for the disease and those who were receiving treatment with endothelin-receptor antagonists or nonintravenous prostanoids. We conducted this 12-week, double-blind, randomized, placebo-controlled trial at 124 centers in giardia paper, 30 countries.
The study was designed by the first author and the steering committee (see the Supplementary Appendix, available with the full text of this article at NEJM.org) in collaboration with the sponsor, Bayer HealthCare. The institutional review board at each participating center approved the descriptive about a waiting, protocol. Data were collected according to Good Clinical Practice guidelines at giardia research, the investigation sites. Essays On Walden Woods? The steering committee had access to research, the complete database. The statistical analysis was performed by a statistician employed by the sponsor and was reviewed by the first author. All the resume halifax ns, drafts of the manuscript were prepared by the first author, and editorial assistance, funded by the sponsor, was provided by Adelphi Communications. The first author, with approval from the coauthors, made the research paper, decision to submit the manuscript for on walden, publication. The academic authors assume full responsibility for the accuracy and completeness of the data and research all the analyses, as well as for the fidelity of this report to the trial protocol, which is available at NEJM.org.
Patients with symptomatic pulmonary arterial hypertension (idiopathic, familial, or associated with connective-tissue disease, congenital heart disease, portal hypertension with liver cirrhosis, or anorexigen or amphetamine use) were included if they had a pulmonary vascular resistance greater than 300 dyn·sec·cm –5 , a mean pulmonary-artery pressure of at least 25 mm Hg, and a 6-minute walk distance of 150 to 450 m. Halifax? Patients who were receiving no other treatment for pulmonary arterial hypertension and paper patients who were receiving treatment with endothelin-receptor antagonists or prostanoids (excluding intravenous prostanoids) at doses that had been stable for at resume halifax, least 90 days were eligible; patients who were receiving phosphodiesterase type 5 inhibitors were not eligible. Giardia? Oral anticoagulant agents, as well as diuretics and supplemental oxygen at stable doses, were also permitted. Written informed consent was obtained from all the french essay, patients. Eligible patients were randomly assigned, in research, a 2:4:1 ratio, to one of three regimens: placebo, oral riociguat administered in thesis, doses that were individually adjusted for each patient up to 2.5 mg three times daily (2.5 mg–maximum group), or oral riociguat administered in individually adjusted doses that were capped at 1.5 mg three times daily (1.5 mg–maximum group). The dose-adjustment plan for riociguat is research described in detail in Fig. Descriptive Essay About? S1 and research paper the section on the dosing regimen in writing, the Supplementary Appendix. Giardia Research Paper? Riociguat therapy was initiated at a dose of essay writing for beginners, 1 mg three times daily, and giardia research the dose was adjusted according to the patient's systolic systemic arterial blood pressure and signs or symptoms of hypotension (final range, 0.5 mg to 2.5 mg three times daily).
The dose reached at the end of the 8-week adjustment phase was considered to be the appropriate dose for the patient, and the patient continued taking the drug at french, that dose for another 4 weeks. In the 1.5 mg–maximum group, therapy was initiated at a dose of 1 mg three times daily, and the dose was adjusted every 2 weeks to paper, a maximum dose of 1.5 mg three times daily. Since no further increase in ns, dose was allowed, patients in giardia research, this group and those in the placebo group underwent sham adjustment of doses to maintain the blinding of the treatment assignments. The 1.5 mg–maximum group was included for exploratory purposes, to provide information about lower riociguat doses, and french essay writing data from that group were not included in the efficacy analyses. Patients were seen at weeks 2, 4, 6, and giardia research 8 (during the essay writing for beginners, dose-adjustment phase) and at giardia paper, week 12 (at the end of the maintenance phase). At each visit, clinical assessments and blood tests were performed. Essays In The? Patients who discontinued therapy for any reason were withdrawn from the trial; these patients underwent an giardia research, efficacy assessment at resume halifax, the termination visit and had no further efficacy assessments after withdrawal. All surviving patients returned for a follow-up assessment of safety at 30 days.
All patients who completed the giardia paper, 12-week PATENT-1 study period were eligible to enter the PATENT-2 long-term extension study. The primary end point was the change from baseline to the end of week 12 in usip essay, the distance walked in 6 minutes. Secondary efficacy end points included changes from baseline to the end of research, week 12 in thesis timeline, pulmonary vascular resistance, N-terminal pro–brain natriuretic peptide (NT-proBNP) levels, World Health Organization (WHO) functional class (an adaptation of the New York Heart Association functional classification), the time to giardia research, clinical worsening (as defined in thesis timeline harvard, the Supplementary Appendix), Borg dyspnea score (which ranges from 0 to 10, with 0 representing no dyspnea and giardia research 10 maximal dyspnea), score on or model persuasive the EuroQol Group 5-Dimension Self-Report Questionnaire (EQ-5D, in which scores range from giardia research, –0.6 to or model body persuasive essay, 1.0, with higher scores indicating better quality of life), and the Living with Pulmonary Hypertension (LPH) questionnaire (an adaptation of the Minnesota Living with Heart Failure Questionnaire, with scores ranging from giardia paper, 0 to 105 and essays woods higher scores indicating worse quality of research, life). Adverse events and laboratory variables were assessed throughout the essay writing for beginners, study and during the safety follow-up period. We calculated that with 250 patients in the 2.5 mg–maximum group and 125 in the placebo group, the study would have 90% power to giardia research paper, detect a least-squares mean difference in the 6-minute walk distance of thesis, 25 m, at a two-sided significance level of 5%. Giardia Research Paper? The primary efficacy analysis was performed on data from the modified intention-to-treat population (all patients who underwent randomization and received at least one dose of the study drug) ( Figure 1 Figure 1 Screening, Randomization, and anorexia or model persuasive Follow-up. The two patients who underwent randomization but did not receive a dose of the study drug (one in the placebo group and one in the 1.5 mg–maximum group) were ineligible for giardia research paper, the study and about a waiting were randomly assigned in error by the investigator. The three deaths during follow-up (two in the 2.5 mg–maximum group and one in the placebo group) occurred in patients who withdrew from the research, study and died during the 30-day follow-up period. Essays On Walden? ). A per-protocol analysis was also performed (see the Supplementary Appendix). Values that were missing owing to withdrawal of a patient from the study or death were imputed as described in giardia research paper, the Supplementary Appendix. The statistical analysis plan was identical to the plan in usip essay, the Chronic Thromboembolic Pulmonary Hypertension Soluble Guanylate Cyclase–Stimulator Trial 1 (CHEST-1). 4 Briefly, the paper, primary end point and the secondary end points that were measured on a semicontinuous scale were analyzed by means of analysis of covariance followed by a test of normality of the residuals and, if rejected, a nonparametric stratified Wilcoxon test.
Changes in the WHO functional class and the Borg dyspnea score were analyzed with the use of usip essay, a stratified Wilcoxon test, and the time to clinical worsening was analyzed with the use of giardia research, a stratified log-rank test. Secondary efficacy variables were tested with the use of a hierarchical testing procedure, in the following order: pulmonary vascular resistance, NT-proBNP level, WHO functional class, time to clinical worsening, score on the Borg dyspnea scale, EQ-5D score, and score on the LPH questionnaire (see the or life, Supplementary Appendix). Safety was analyzed descriptively. Adverse events during the research, study period included all adverse events that started or worsened from the time of administration of the first dose of the study drug until 2 days after administration of the last dose. Further details regarding the statistical analysis are provided in the Supplementary Appendix. From December 2008 through February 2012, a total of 443 patients were randomly assigned to receive placebo (126 patients), riociguat at thesis timeline, individually adjusted doses up to 2.5 mg three times daily (254 patients), or riociguat at giardia paper, individually adjusted doses capped at 1.5 mg three times daily (63 patients) ( Figure 1 ). The baseline characteristics of the essays or life, patients were well balanced among the groups ( Table 1 Table 1 Baseline Demographic and Clinical Characteristics of the Patients. ). Idiopathic pulmonary arterial hypertension was the most common diagnosis, and giardia research the majority of halifax ns, patients were in WHO functional class II or III.
A total of research paper, 44% of the patients were receiving treatment with endothelin-receptor antagonists (primarily bosentan), and 6% were receiving prostanoid therapy (primarily inhaled iloprost); 50% were receiving no other treatment for pulmonary arterial hypertension. A total of 38 patients withdrew from the study before week 12 ( Figure 1 ). In the 2.5 mg–maximum group, 75% of the patients were receiving the maximal dose at week 12, 15% were receiving 2.0 mg three times daily, 6% 1.5 mg three times daily, 3% 1.0 mg three times daily, and 2% 0.5 mg three times daily. French For Beginners? The dose of the study drug was decreased in 31 patients (12%) in this group as compared with 11 patients (9%) in the placebo group. In the paper, 1.5 mg–maximum group, 96% of the patients were receiving 1.5 mg three times daily at week 12. At week 12, the essays on walden in the woods, 6-minute walk distance had increased from baseline by a mean of 30 m in the 2.5 mg–maximum group and had decreased by a mean of 6 m in the placebo group (least-squares mean difference, 36 m; 95% confidence interval [CI], 20 to 52; P0.001), on the basis of an analysis of the modified intention-to-treat population with missing values imputed ( Table 2 Table 2 Change from Baseline to giardia research paper, End of Week 12 in Primary and resume halifax Secondary End Points and Hemodynamic Variables. and giardia Figure 2 Figure 2 Mean Change from Baseline in the 6-Minute Walk Distance. Mean (±SE) changes from baseline in the distance walked in 6 minutes during the 12-week PATENT-1 study period are shown in the group that received riociguat at a dose up to 2.5 mg three times daily as compared with the essays or life in the, placebo group. The data were analyzed in the modified intention-to-treat population without imputation of missing values; imputed values are provided at paper, week 12. Resume? The number at research, each data point indicates the number of patients included in the assessment at that time point.
The least-squares mean difference in the 6-minute walk distance at week 12 was 36 m (95% CI, 20 to 52; P0.001). The last observed value (not including follow-up) was carried forward for patients who completed the body, study or withdrew; the research, worst value (0 m) was imputed in the case of death or clinical worsening without a termination visit or without a measurement at the termination visit. ). The benefit with riociguat was similar (Table S1 in the Supplementary Appendix) in descriptive room, sensitivity analyses for giardia paper, missing data that used statistical methods for longitudinal data, as described in the Supplementary Appendix. The increase in the 6-minute walk distance in the per-protocol population (Table S2 in the Supplementary Appendix) was consistent with the resume halifax, increase in the main analysis. The treatment effect was consistent in giardia research, several patient subgroups, including subgroups defined according to status with respect to treatment with additional agents for pulmonary arterial hypertension (Fig. Harvard? S2 and Table S3 in the Supplementary Appendix). As anticipated, there was statistical evidence of heterogeneity of the treatment effect in subgroups defined according to WHO functional class; patients in giardia research, functional class III or IV had a significantly greater benefit with riociguat therapy than did those in functional class I or II. Secondary End Points in the 2.5 mg–Maximum Group versus the Placebo Group. Pulmonary vascular resistance decreased by 223 dyn·sec·cm –5 in the 2.5 mg–maximum group, as compared with 9 dyn·sec·cm –5 in the placebo group (least-squares mean difference, –226 dyn·sec·cm –5 ; 95% CI, –281 to descriptive essay, –170; P0.001) ( Table 2 ). Significant improvements in paper, other hemodynamic variables, including mean pulmonary-artery pressure and descriptive a waiting room cardiac output, were also evident in giardia paper, patients treated with riociguat ( Table 2 ). Significant benefits were seen in the 2.5 mg–maximum group, as compared with the placebo group, with respect to other secondary end points, including NT-proBNP levels, WHO functional class, and score on the Borg dyspnea scale ( Table 2 ). There was also a significantly lower incidence of usip essay, events indicating clinical worsening in the 2.5 mg–maximum group than in research, the placebo group ( Table 3 Table 3 Clinical Worsening and Adverse Events. ). The Kaplan–Meier estimates of the proportion of patients with clinical worsening are provided in Fig. S3 in the Supplementary Appendix. The EQ-5D score did not differ significantly between the 2.5 mg–maximum group and the placebo group (P=0.07).
On the basis of the prespecified hierarchical testing procedure, the analysis of the usip essay, scores on the LPH questionnaire was considered to be exploratory (Table S4 in the Supplementary Appendix); there was a nominally significant difference between the research, 2.5 mg–maximum group and ns the placebo group in that secondary outcome ( Table 2 ). End Points in the 1.5 mg–Maximum Group. The analysis of the 1.5 mg–maximum group was exploratory, and data from that group were not included in the efficacy analyses. The results with respect to the primary and secondary end points in this group are shown in Table S5 in the Supplementary Appendix. Safety Results in giardia, the 2.5 mg–Maximum Group and the Placebo Group. The adverse events that occurred most frequently during the study period are shown in Table 3 . The most frequently occurring serious adverse events were syncope (in 1% of the patients in the 2.5 mg–maximum group vs. Anorexia Or Model Persuasive? 4% in the placebo group), worsening pulmonary hypertension (in 1% of the patients in the 2.5 mg–maximum group vs. 2% in the placebo group), chest pain (in 1% of the patients in both the 2.5 mg–maximum group and the placebo group), and right ventricular failure (in 1% of the patients in both groups).
Drug-related serious adverse events in research, the 2.5 mg–maximum group included three cases of syncope (in 1% of the thesis timeline harvard, patients) and giardia single cases of increased hepatic enzyme levels, dizziness, presyncope, acute renal failure, and hypotension (in a total of 0.4% of the patients), and in or model body, the placebo group, single cases of diarrhea, presyncope, syncope, dyspnea, and worsening pulmonary hypertension (in a total of 1% of the patients). Eight patients (3%) in the 2.5 mg–maximum group and nine patients (7%) in the placebo group discontinued the study drug owing to research paper, adverse events. The following events leading to discontinuation of the thesis timeline, study drug were considered by the investigator to be drug-related adverse or serious adverse events: in the 2.5 mg–maximum group, increased hepatic enzyme levels (serious), acute renal failure (serious), syncope (serious), esophageal pain and paper esophageal swelling, supraventricular tachycardia, hypotension, generalized edema, and resume neck pain; in the placebo group, diarrhea, syncope (serious), dyspnea, hypoxemia (serious), and worsening of paper, pulmonary hypertension (serious). Deaths related to adverse events occurred in two patients (1%) in the 2.5 mg–maximum group (one each from sepsis and writing for beginners hemoptysis) and in three patients (2%) in the placebo group (one each from giardia, worsening anxiety followed by acute respiratory failure, worsening pulmonary hypertension, and respiratory failure); none of the essay for beginners, deaths were considered to be related to the study drug. A total of 396 patients (98% of the giardia paper, patients who completed the study) entered the long-term extension study PATENT-2, in which the treatment assignments were concealed for the first 8 weeks and treatment was open-label thereafter. Essay Writing? Of these patients, 363 patients (308 of whom were still receiving treatment at giardia research paper, a median of 441 days) were included in an interim analysis of data collected up to April 2012. An exploratory analysis of the first 12 weeks of PATENT-2 showed further increases in usip essay, the 6-minute walk distance in the 215 patients receiving up to 2.5 mg of giardia, riociguat three times daily. Or Model? A mean (±SD) increase of 53±62 m over the baseline distance in PATENT-1 among these 215 patients was observed at paper, week 12 of PATENT-2. Halifax Ns? The same group had had an increase of 36±54 m at week 12 of PATENT-1.
In this trial, riociguat significantly improved exercise capacity in patients with pulmonary arterial hypertension. This benefit was consistent in patients who were receiving endothelin-receptor antagonists or prostanoids and in those who were receiving no other treatment for the disease. Riociguat also significantly and consistently improved a range of secondary efficacy end points, including pulmonary hemodynamics, WHO functional class, and time to paper, clinical worsening. Although some studies suggest that the 6-minute walk distance has modest validity as a surrogate end point for clinical events, 8 it is the on walden woods, most frequently used primary end point in randomized, controlled trials involving patients with pulmonary arterial hypertension, 9 is an independent predictor of giardia research, death, 10 and correlates with changes in functional status and hemodynamic variables and with survival. Usip Essay? 11 The overall difference in the 6-minute walk distance with riociguat as compared with placebo (36 m) at 12 weeks is consistent with the increases observed in previous studies of other medications for the treatment of pulmonary arterial hypertension (16 to 59 m). 12-17 Furthermore, these improvements were maintained during the giardia, first 12 weeks of the resume halifax ns, long-term extension study. The improvement in the 6-minute walk distance with riociguat as compared with placebo is also within the range of thresholds that have previously been reported to research paper, represent a clinically relevant change (31 to 42 m).
8,18,19 However, a large proportion of or life in the, patients in PATENT-1 had WHO functional class II symptoms at giardia paper, baseline and timeline harvard a baseline 6-minute walk distance that was relatively long; thus, this population had less advanced illness than did the population in many previous studies. Indeed, there was statistical evidence from a subgroup analysis that WHO functional class influenced the beneficial effect of research paper, riociguat on the 6-minute walk distance — a finding that was anticipated from previous observations 13,15 — suggesting that the benefit with riociguat is more likely to for beginners, be clinically important in patients with WHO functional class III or IV symptoms than in giardia research paper, those with class I or II symptoms. The inclusion in PATENT-1 of patients who were receiving endothelin-receptor antagonists or prostanoids also warrants consideration, since the clinically relevant thresholds for 6-minute walk distance may not be accurate for patients receiving background therapy. Another study, the Pulmonary Arterial Hypertension and woods Response to research, Tadalafil (PHIRST) study, 15 closely resembled PATENT-1 with respect to both the patient population and the study design, since the PHIRST study included both patients who had received or were currently receiving no treatment for the disease and patients who were receiving endothelin-receptor antagonists. Essays On Walden? However, in the PHIRST study, patients receiving background endothelin-receptor–antagonist therapy did not have significant improvements in the 6-minute walk distance, whereas in PATENT-1, riociguat improved the 6-minute walk distance in research, both patients who were receiving no therapy for the disease and patients who were receiving endothelin-receptor antagonists or prostanoids. In PATENT-1, riociguat was associated with consistent improvements across a range of thesis, clinically relevant primary and giardia paper secondary end points, including 6-minute walk distance, pulmonary vascular resistance, and time to clinical worsening — improvements that were not seen in some previous trials.
Delays in clinical worsening are considered to be clinically relevant, 20 and the delay in clinical worsening that was observed in or life woods, PATENT-1 was consistent with the greater number of giardia paper, patients with improved or stable WHO functional class in the group receiving riociguat at anorexia essay, a dose up to 2.5 mg three times daily than in giardia, the placebo group. The hemodynamic improvements observed with riociguat require further characterization but could be related to disease-modifying effects, such as antifibrotic, antiproliferative, and antiinflammatory effects, that were observed in preclinical studies. 21-25 In addition, the increase in cardiac output was reflected by a decrease in NT-proBNP levels, which could be indicative of decreased right ventricular afterload. An obvious limitation of thesis harvard, PATENT-1 was the lack of follow-up efficacy measurements in patients who withdrew from the study. However, sensitivity analyses that were performed with a variety of approaches to impute missing data suggest that the results are dependable despite these losses to follow-up.
Another limitation was the exclusion of patients with pulmonary arterial hypertension associated with human immunodeficiency virus infection, schistosomiasis, and chronic hemolytic anemia. Patients who were receiving treatment with phosphodiesterase type 5 inhibitors or intravenous prostanoids were also excluded from PATENT-1, and the effect of giardia research, riociguat in such patients is unknown. In conclusion, riociguat significantly improved the 6-minute walk distance, as well as pulmonary vascular resistance and several other secondary efficacy end points, in patients with symptomatic pulmonary arterial hypertension who were receiving no other treatment for anorexia essay, the disease or who were receiving endothelin-receptor antagonists or prostanoids. Supported by Bayer HealthCare. Disclosure forms provided by the authors are available with the full text of this article at NEJM.org. We thank Mike Kenward, Ph.D., from the London School of Hygiene and Tropical Medicine for advice on the missing-data sensitivity analysis.
From the giardia, University of Giessen and Marburg Lung Center, Giessen, member of the German Center for thesis timeline, Lung Research (H.-A.G., F.G.), Center for Pulmonary Hypertension, Thoraxclinic, University Hospital Heidelberg, Heidelberg (E.G.), and Global Clinical Development, Bayer HealthCare, Wuppertal (A.F., D.N.) — all in research paper, Germany; Department of Medicine, Imperial College London, London (H.-A.G.); Department of Experimental, Diagnostic, and Specialty Medicine, Bologna University Hospital, Bologna (N.G.), and Global Clinical Development, Bayer HealthCare, Milan (M.O.K.) — both in Italy; Assistance Publique–Hopitaux de Paris, Service de Pneumologie, Hopital Bicetre, Universite Paris-Sud, Laboratoire d'Excellence en Recherche sur le Medicament et Innovation Therapeutique, and anorexia or model persuasive essay INSERM Unite 999, Le Kremlin–Bicetre, France (M.H.); State Key Laboratory of paper, Cardiovascular Disease, Fu Wai Hospital, Peking Union Medical College and essays on walden or life in the woods Chinese Academy of research, Medical Sciences, Beijing (Z.-C.J.); St. Vincent's Hospital, Sydney (A.M.K.); Center for for beginners, Pulmonary Vascular Disease and research paper Lady Davis Institute, Jewish General Hospital, McGill University, Montreal (D.L.); and University of California, San Diego, La Jolla (L.J.R.). Address reprint requests to Dr. Ghofrani at the Department of anorexia or model persuasive essay, Internal Medicine, Medical Clinic II/V, University Hospital Giessen and Marburg, Klinikstr. 33, Giessen 35392, Germany, or at firstname.lastname@example.org. The full list of investigators and trial committees of the giardia, Pulmonary Arterial Hypertension Soluble Guanylate Cyclase–Stimulator Trial 1 (PATENT-1) Study Group is provided in the Supplementary Appendix, available at NEJM.org.
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Mateo Porres-Aguilar, Debabrata Mukherjee. . (2015) Portopulmonary hypertension: An update. Respirology 20 :2, 235-242. Rodrigo Cartin-Ceba, Michael J. Krowka. . Research? 2015. Portopulmonary hypertension. Anorexia Body? Cirrhosis: A practical guide to management, 212-224. A Dasgupta, L Bowman, CL D'Arsigny, SL Archer. . (2015) Soluble Guanylate Cyclase: A New Therapeutic Target for Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension. Research? Clinical Pharmacology Therapeutics 97 :1, 88-102. Richard N. Resume Halifax? Channick, Marion Delcroix, Hossein-Ardeschir Ghofrani, Elke Hunsche, Pavel Jansa, Franck-Olivier Le Brun, Sanjay Mehta, Tomas Pulido, Lewis J. Rubin, B.K.S. Sastry, Gerald Simonneau, Olivier Sitbon, Rogerio Souza, Adam Torbicki, Nazzareno Galie. Paper? . Essay Room? (2015) Effect of Macitentan on paper Hospitalizations.
JACC: Heart Failure 3 :1, 1-8. Takeo Fujino, Atsushi Yao, Masaru Hatano, Toshiro Inaba, Hironori Muraoka, Shun Minatsuki, Teruhiko Imamura, Hisataka Maki, Koichiro Kinugawa, Minoru Ono, Ryozo Nagai, Issei Komuro. . (2015) Targeted Therapy Is Required for halifax, Management of research paper, Pulmonary Arterial Hypertension After Defect Closure in Adult Patients With Atrial Septal Defect and Associated Pulmonary Arterial Hypertension. International Heart Journal 56 :1, 86-93. Jared Grochowsky, Joseph Ming Wah Li. . (2015) New Drugs in 2013. Halifax? Hospital Medicine Clinics 4 :1, 128-133. Koichiro Tatsumi. . Giardia? (2015) 5. Pulmonary Hypertension: Crosstalk between Respiration and Circulation. Descriptive Essay A Waiting Room? Nihon Naika Gakkai Zasshi 104 :9, 1944-1952. Dustin R. Fraidenburg, Jason X.-J.
Yuan, Sean P. Gaine. . 2015. Paper? Diagnosis and or life in the Treatment of Pulmonary Arterial Hypertension. PanVascular Medicine, 4105-4133. Bhaumik B. Patel, Ying Feng, Angela Cheng-Lai. . (2015) Pulmonary Arterial Hypertension. Cardiology in Review 23 :1, 33-51. Ayodeji Adegunsoye, Matthew Levy, Olusegun Oyenuga. . (2015) Novel Therapeutic Strategies for Reducing Right Heart Failure Associated Mortality in giardia, Fibrotic Lung Diseases.
BioMed Research International 2015 , 1-16. Dustin R. Fraidenburg, Jason X.-J. Yuan. . Usip Essay? 2015. Giardia Paper? Pathogenic Mechanisms of usip essay, Pulmonary Hypertension. PanVascular Medicine, 4079-4104. Wiebke Janssen, Yves Schymura, Tatyana Novoyatleva, Baktybek Kojonazarov, Mario Boehm, Astrid Wietelmann, Himal Luitel, Kirsten Murmann, Damian Richard Krompiec, Aleksandra Tretyn, Soni Savai Pullamsetti, Norbert Weissmann, Werner Seeger, Hossein Ardeschir Ghofrani, Ralph Theo Schermuly. . (2015) 5-HT2B Receptor Antagonists Inhibit Fibrosis and Protect from RV Heart Failure. BioMed Research International 2015 , 1-8. A.M. Giardia? Chakrabarti, J.A.
Mitchell, S.J. Wort. . (2015) Progress in the understanding and management of essay, pulmonary arterial hypertension. Global Cardiology Science and Practice 2015 :1, 13. S. A. Pilkington, D. Taboada, G. Martinez. . (2015) Pulmonary hypertension and its management in patients undergoing non-cardiac surgery. Anaesthesia 70 :1, 56-70. Tsutomu Saji, Tomotaka Nakayama, Shinichi Takatsuki, Satoshi Ikehara, Hiromitsu Shimada, Kazuyuki Naoi, Mari Sato, Hiroyuki Matsuura. . (2015) The Real World of Medical Treatment of Pulmonary Arterial Hypertension?Small Evidence, but Heavy Cornerstone?.
Pediatric Cardiology and Cardiac Surgery 31 :4, 157-183. Stephen C. Mathai, Paul M. Hassoun, Milo A. Puhan, Yi Zhou, Robert A. Wise. . (2015) Sex Differences in Response to Tadalafil in Pulmonary Arterial Hypertension. Chest 147 :1, 188-197. Michael Irlbeck, Marlis Irlbeck, Bernhard Zwi?ler. Research? . 2015. Herz-Kreislauf-wirksame Medikamente in der Anasthesiologie. Die Anasthesiologie, 1-26.
Namita Sood. Descriptive Essay About A Waiting? . (2014) Macitentan for the treatment of pulmonary arterial hypertension. Expert Opinion on research paper Pharmacotherapy 15 :18, 2733-2739. Julie L. Rosenthal, Miriam S. Jacob. . Harvard? (2014) Biomarkers in Pulmonary Arterial Hypertension. Current Heart Failure Reports 11 :4, 477-484. Nika Skoro-Sajer, Irene Lang. . (2014) Extended-release oral treprostinil for the treatment of research paper, pulmonary arterial hypertension. Expert Review of Cardiovascular Therapy 12 :12, 1391-1399. Tim P Morris, Brennan C Kahan, Ian R White. . (2014) Choosing sensitivity analyses for randomised trials: principles. BMC Medical Research Methodology 14 :1.
Ya-Guo Zheng, Hong Ma, En-Ci Hu, Gang Liu, Guo Chen, Chang-Ming Xiong. . Essay A Waiting? (2014) Oral targeted therapies in the treatment of pulmonary arterial hypertension: A meta-analysis of paper, clinical trials. Pulmonary Pharmacology Therapeutics 29 :2, 241-249. Andrea Olschewski, Rita Papp, Chandran Nagaraj, Horst Olschewski. . (2014) Ion channels and transporters as therapeutic targets in the pulmonary circulation. Pharmacology Therapeutics 144 :3, 349-368. Aaron M. Wolfson, Nathaniel Steiger, Mardi Gomberg-Maitland. . (2014) New Pharmacotherapies for Pulmonary Hypertension: Where Do They Fit in?. Current Hypertension Reports 16 :12.
Michael A. Gatzoulis, Maurice Beghetti, Michael J. Ns? Landzberg, Nazzareno Galie. . (2014) Pulmonary arterial hypertension associated with congenital heart disease: Recent advances and giardia paper future directions. International Journal of resume, Cardiology 177 :2, 340-347. Evan L. Giardia? Brittain, David R. Janz, Eric D. Austin, Julie A. Bastarache, Lisa A. Wheeler, Lorraine B. Ware, Anna R. Thesis Timeline? Hemnes. Giardia Research? . (2014) Elevation of Plasma Cell-Free Hemoglobin in Pulmonary Arterial Hypertension. Chest 146 :6, 1478-1485. Tobias Meis, Juergen Behr. . (2014) Riociguat for the treatment of pulmonary hypertension. Expert Opinion on Pharmacotherapy 15 :16, 2419-2427. Karly P. Garnock-Jones. Essays In The Woods? . (2014) Riociguat: A Review of giardia paper, Its Use in Patients with Chronic Thromboembolic Pulmonary Hypertension or Pulmonary Arterial Hypertension. Drugs 74 :17, 2065-2078. Joan Albert Barbera. . (2014) Clinical Research in Pulmonary Hypertension Comes of usip essay, Age. Research? Archivos de Bronconeumologia (English Edition) 50 :11, 463-464.
Joan Albert Barbera. . (2014) La investigacion clinica en hipertension pulmonar ha alcanzado la mayoria de edad. Archivos de Bronconeumologia 50 :11, 463-464. Diana Bonderman, Ingrid Pretsch, Regina Steringer-Mascherbauer, Pavel Jansa, Stephan Rosenkranz, Caroline Tufaro, Andja Bojic, Carolyn S. P Lam, Reiner Frey, Michael Ochan Kilama, Sigrun Unger, Lothar Roessig, Irene M Lang. . (2014) Acute Hemodynamic Effects of Riociguat in Patients With Pulmonary Hypertension Associated With Diastolic Heart Failure (DILATE-1). Chest 146 :5, 1274-1285. Wim A Wuyts, Katerina M Antoniou, Keren Borensztajn, Ulrich Costabel, Vincent Cottin, Bruno Crestani, Jan C Grutters, Toby M Maher, Venerino Poletti, Luca Richeldi, Carlo Vancheri, Athol U Wells. Anorexia Body Essay? . Paper? (2014) Combination therapy: the descriptive about a waiting, future of management for idiopathic pulmonary fibrosis?. The Lancet Respiratory Medicine 2 :11, 933-942. Maurice Beghetti, Julie Wacker Bou Puigdefabregas, Sausan Merali. . (2014) Sildenafil for the treatment of pulmonary hypertension in children. Expert Review of Cardiovascular Therapy 12 :10, 1157-1184. Willemijn MH Zijlstra, Mark-Jan Ploegstra, Rolf MF Berger. Research? . (2014) Current and advancing treatments for anorexia or model essay, pulmonary arterial hypertension in childhood. Giardia Paper? Expert Review of Respiratory Medicine 8 :5, 615-628.
Hiromi Matsubara, Aiko Ogawa. Body Persuasive? . (2014) Treatment of idiopathic/hereditary pulmonary arterial hypertension. Journal of Cardiology 64 :4, 243-249. Paul M. Paper? Hassoun, Paul T. Schumacker. . Usip Essay? (2014) Update in Pulmonary Vascular Diseases 2013. Giardia Paper? American Journal of Respiratory and Critical Care Medicine 190 :7, 738-743. Egbert Bisping, Paulina Wakula, Michael Poteser, Frank R. Heinzel. Usip Essay? . (2014) Targeting Cardiac Hypertrophy. Journal of Cardiovascular Pharmacology 64 :4, 293-305. Lisa L. Dupont, Constantinos Glynos, Ken R. Bracke, Peter Brouckaert, Guy G. Brusselle. . (2014) Role of the nitric oxide–soluble guanylyl cyclase pathway in research paper, obstructive airway diseases. Pulmonary Pharmacology Therapeutics 29 :1, 1-6. Mohamed A. Or Model Persuasive Essay? Gashouta, Marc Humbert, Paul M. Hassoun. . (2014) Update in paper, systemic sclerosis-associated pulmonary arterial hypertension. La Presse Medicale 43 :10, e293-e304. Lisa M. Mielniczuk, John R. Swiston, Sanjay Mehta. . (2014) Riociguat: A Novel Therapeutic Option for Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension.
Canadian Journal of descriptive essay about, Cardiology 30 :10, 1233-1240. Jose Gomez-Arroyo, Julio Sandoval, Marc A. Simon, Erick Dominguez-Cano, Norbert F. Giardia Research? Voelkel, Harm J. Bogaard. . Descriptive About Room? (2014) Treatment for Pulmonary Arterial Hypertension–Associated Right Ventricular Dysfunction. Annals of the research paper, American Thoracic Society 11 :7, 1101-1115. Olivier Sitbon, Laurent Savale, Xavier Jais, David Montani, Marc Humbert, Gerald Simonneau. . (2014) Traitement de l’hypertension arterielle pulmonaire. La Presse Medicale 43 :9, 981-993.
Burkert Pieske, Javed Butler, Gerasimos Filippatos, Carolyn Lam, Aldo Pietro Maggioni, Piotr Ponikowski, Sanjiv Shah, Scott Solomon, Elisabeth Kraigher-Krainer, Eliana Tibana Samano, Andrea Viviana Scalise, Katharina Muller, Lothar Roessig, Mihai Gheorghiade, . Usip Essay? . Research? (2014) Rationale and design of the french essay for beginners, SOluble guanylate Cyclase stimulatoR in heArT failurE Studies (SOCRATES). European Journal of Heart Failure 16 :9, 1026-1038. Suman Gidwani, Ajith Nair. . (2014) The Burden of Pulmonary Hypertension in Resource-Limited Settings. Global Heart 9 :3, 297-310. Gilles Rival, Yves Lacasse, Sylvie Martin, Sebastien Bonnet, Steeve Provencher. Paper? . (2014) Effect of Pulmonary Arterial Hypertension-Specific Therapies on Health-Related Quality of essays on walden woods, Life. Giardia Research Paper? Chest 146 :3, 686-708. David Kylhammar, Liselotte Persson, Roger Hesselstrand, Goran Radegran. . (2014) Prognosis and response to first-line single and on walden or life in the woods combination therapy in pulmonary arterial hypertension. Research Paper? Scandinavian Cardiovascular Journal 48 :4, 223-233. Verena Rickert, Walter Emil Haefeli, Johanna Weiss. Halifax Ns? . (2014) Pharmacokinetic interaction profile of riociguat, a new soluble guanylate cyclase stimulator, in research, vitro. Pulmonary Pharmacology Therapeutics 28 :2, 130-137. Linda S. Hoffmann, Horng H. Chen. . Anorexia Body Essay? (2014) cGMP: transition from bench to bedside: a report of the 6th International Conference on cGMP Generators, Effectors and Therapeutic Implications.
Naunyn-Schmiedeberg's Archives of Pharmacology 387 :8, 707-718. Sonja D. Bartolome. . (2014) Portopulmonary hypertension: Diagnosis, clinical features, and medical therapy. Clinical Liver Disease 4 :2, 42-45. Thomas Viethen, Felix Gerhardt, Daniel Dumitrescu, Susanne Knoop-Busch, Henrik ten Freyhaus, Tanja K. Rudolph, Stephan Baldus, Stephan Rosenkranz. . (2014) Ferric carboxymaltose improves exercise capacity and quality of life in patients with pulmonary arterial hypertension and iron deficiency: A pilot study. International Journal of giardia research, Cardiology 175 :2, 233-239. Daniela Fraccarollo, Paolo Galuppo, Stephanie Motschenbacher, Hartmut Ruetten, Andreas Schafer, Johann Bauersachs. . (2014) Soluble guanylyl cyclase activation improves progressive cardiac remodeling and failure after myocardial infarction. Cardioprotection over ACE inhibition. Basic Research in Cardiology 109 :4. Rocco Ciraci, Giampaolo Tirone, Francesco Scaglione. . (2014) The impact of drug–drug interactions on pulmonary arterial hypertension therapy. Pulmonary Pharmacology Therapeutics 28 :1, 1-8. Karim Said. Usip Essay? . (2014) Riociguat: PATENT-1 Study.
Global Cardiology Science and Practice 2014 :2, 21. J. Lundgren, G. Research? Radegran. . (2014) Pathophysiology and potential treatments of pulmonary hypertension due to systolic left heart failure. Acta Physiologica 211 :2, 314-333. C. Beyer, J.H.W. Distler. . (2014) Mechanismen der Fibrose und ihre Translation in die Klinik. Zeitschrift fur Rheumatologie 73 :5, 458-460.
Norbert Weissmann, Borja Lobo, Alexandra Pichl, Nirmal Parajuli, Michael Seimetz, Raquel Puig-Pey, Elisabet Ferrer, Victor I. Essay A Waiting Room? Peinado, David Dominguez-Fandos, Athanasios Fysikopoulos, Johannes-Peter Stasch, Hossein A. Ghofrani, Nuria Coll-Bonfill, Reiner Frey, Ralph T. Schermuly, Jessica Garcia-Lucio, Isabel Blanco, Mariola Bednorz, Olga Tura-Ceide, Elsa Tadele, Ralf P. Brandes, Jan Grimminger, Walter Klepetko, Peter Jaksch, Robert Rodriguez-Roisin, Werner Seeger, Friedrich Grimminger, Joan A. Barbera. . (2014) Stimulation of Soluble Guanylate Cyclase Prevents Cigarette Smoke–induced Pulmonary Hypertension and Emphysema. American Journal of Respiratory and Critical Care Medicine 189 :11, 1359-1373. Michael J. Krowka, Rodrigo Cartin-Ceba. Giardia? . (2014) Portopulmonary hypertension: Formidable dual threat versus hopeful dual therapy. Liver Transplantation 20 :6, 635-636. Emmanuel S. Buys, Lincoln R. On Walden Or Life In The? Potter, Louis R. Pasquale, Bruce R. Giardia Research Paper? Ksander. . (2014) Regulation of anorexia body essay, intraocular pressure by soluble and membrane guanylate cyclases and paper their role in french, glaucoma. Frontiers in Molecular Neuroscience 7 . Ulrike Kraemer, Enno Wildschuth, Dick Tibboel. . Research Paper? (2014) “Out of the Blue”–Safety and Efficacy of or model persuasive essay, Pulmonary Hypertension Treatment in paper, Childhood*.
Pediatric Critical Care Medicine 15 :4, 377-378. Rita Nogueira-Ferreira, Rita Ferreira, Tiago Henriques-Coelho. Or Model Body Persuasive Essay? . (2014) Cellular interplay in pulmonary arterial hypertension: Implications for new therapies. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1843 :5, 885-893. Rodrigo Cartin-Ceba, Michael J. Giardia Research? Krowka. . (2014) Portopulmonary Hypertension. Clinics in a waiting, Liver Disease 18 :2, 421-438. John E Cannon, Joanna Pepke-Zaba. Giardia Research Paper? . (2014) Riociguat for timeline, pulmonary hypertension.
Expert Review of Clinical Pharmacology 7 :3, 259-270. Franziska Seeger, Royston Quintyn, Akiko Tanimoto, Gareth J. Williams, John A. Tainer, Vicki H. Giardia? Wysocki, Elsa D. Essays Woods? Garcin. . (2014) Interfacial Residues Promote an Optimal Alignment of the giardia paper, Catalytic Center in Human Soluble Guanylate Cyclase: Heterodimerization Is Required but Not Sufficient for Activity. Biochemistry 53 :13, 2153-2165. Natasha M. French Writing? Rogers, Franziska Seeger, Elsa D. Garcin, David D. Roberts, Jeffrey S. Isenberg. . (2014) Regulation of soluble guanylate cyclase by matricellular thrombospondins: implications for blood flow. Frontiers in Physiology 5 . Natascha Troster, Gabor Kovacs, Horst Olschewski. . (2014) Kurzatmiger Patient — nicht immer ist er nur untrainiert. MMW - Fortschritte der Medizin 156 :7, 49-54. U. Muller-Ladner, U. Giardia? Lange. . Resume? (2014) Neue Medikamente in der Rheumatologie. Der Internist 55 :4, 377-381.
Emmanuel Buys, Patrick Sips. . (2014) New insights into the role of giardia research paper, soluble guanylate cyclase in blood pressure regulation. Current Opinion in Nephrology and Hypertension 23 :2, 135-142. Vedant Gupta, Richard A Krasuski. . (2014) Inhaled treprostinil sodium for essay, pulmonary hypertension. Expert Opinion on Orphan Drugs 2 :3, 283-291. Soni Savai Pullamsetti, Ralph Schermuly, Ardeschir Ghofrani, Norbert Weissmann, Friedrich Grimminger, Werner Seeger. . Giardia Research Paper? (2014) Novel and Emerging Therapies for Pulmonary Hypertension. American Journal of Respiratory and Critical Care Medicine 189 :4, 394-400. Opher Gileadi. . (2014) Structures of soluble guanylate cyclase: implications for regulatory mechanisms and drug development. Biochemical Society Transactions 42 :1, 108-113.
Nika Skoro-Sajer, Irene Marthe Lang. . Halifax Ns? (2014) Selexipag for the treatment of research paper, pulmonary arterial hypertension. Expert Opinion on Pharmacotherapy 15 :3, 429-436. Saman Ahmed, Harold I. Writing For Beginners? Palevsky. . (2014) Pulmonary Arterial Hypertension Related to Connective Tissue Disease. Rheumatic Disease Clinics of North America 40 :1, 103-124. Erika E. Giardia Research? Vorhies, David Dunbar Ivy. . French? (2014) Drug Treatment of giardia research, Pulmonary Hypertension in essay, Children. Pediatric Drugs 16 :1, 43-65. G. Research? Strange, T. Williams, F. Kermeen, K. Whyte, A. Essay Writing For Beginners? Keogh. . Paper? (2014) Pulmonary hypertension and breathlessness: is it a combination we can ignore?. Internal Medicine Journal 44 :2, 114-123. S. Rosenkranz. . Usip Essay? (2014) Cor pulmonale und pulmonale Hypertonie.
Herz 39 :1, 58-65. Rahul Purohit, Bradley G. Fritz, Juliana The, Aaron Issaian, Andrzej Weichsel, Cynthia L. David, Eric Campbell, Andrew C. Hausrath, Leida Rassouli-Taylor, Elsa D. Garcin, Matthew J. Gage, William R. Montfort. . (2014) YC-1 Binding to research paper, the ? Subunit of Soluble Guanylyl Cyclase Overcomes Allosteric Inhibition by the ? Subunit. Essays On Walden Woods? Biochemistry 53 :1, 101-114. Amirmasoud Zangiabadi, Carmine G. De Pasquale, Dimitar Sajkov. Giardia Research Paper? . (2014) Pulmonary Hypertension and Right Heart Dysfunction in french for beginners, Chronic Lung Disease. BioMed Research International 2014 , 1-13. Salvatore Rosanio, Francesco Pelliccia, Carlo Gaudio, Cesare Greco, Abdul M. Keylani, Darrin C. Giardia Research Paper? D’Agostino. . (2014) Pulmonary Arterial Hypertension in Adults: Novel Drugs and Catheter Ablation Techniques Show Promise? Systematic Review on Pharmacotherapy and Interventional Strategies. Essays On Walden In The Woods? BioMed Research International 2014 , 1-17. Thomas Horvatits, Valentin Fuhrmann. . (2014) Therapeutic options in pulmonary hepatic vascular diseases.
Expert Review of Clinical Pharmacology 7 :1, 31-42. Natalie Sampson, Peter Berger, Christoph Zenzmaier. . (2014) Redox Signaling as a Therapeutic Target to Inhibit Myofibroblast Activation in Degenerative Fibrotic Disease. BioMed Research International 2014 , 1-14. Nicole Luneburg, Lars Harbaum, Jan K. Hennigs. . (2014) The Endothelial ADMA/NO Pathway in Hypoxia-Related Chronic Respiratory Diseases. BioMed Research International 2014 , 1-11. Joanne Bronson, Amelia Black, Murali Dhar, Bruce Ellsworth, J. Robert Merritt. . 2014. To Market, To Market—2013. Annual Reports in Medicinal Chemistry, 437-508. Mala Sharma, Sowmya Pinnamaneni, Wilbert S. Aronow, Bartosz Jozwik, William H. Giardia Research Paper? Frishman. Thesis Harvard? . (2014) Existing Drugs and Agents Under Investigation for Pulmonary Arterial Hypertension. Cardiology in Review 22 :6, 297-305.
Carmen Methner, Guido Buonincontri, Chou-Hui Hu, Ana Vujic, Axel Kretschmer, Stephen Sawiak, Adrian Carpenter, Johannes-Peter Stasch, Thomas Krieg, Fadi N. Salloum. . (2013) Riociguat Reduces Infarct Size and Post-Infarct Heart Failure in Mouse Hearts: Insights from MRI/PET Imaging. PLoS ONE 8 :12, e83910. (2013) Riociguat for giardia paper, Pulmonary Hypertension. New England Journal of Medicine 369 :23, 2266-2268. Werner Seeger, Yochai Adir, Joan Albert Barbera, Hunter Champion, John Gerard Coghlan, Vincent Cottin, Teresa De Marco, Nazzareno Galie, Stefano Ghio, Simon Gibbs, Fernando J. Martinez, Marc J. Semigran, Gerald Simonneau, Athol U. Wells, Jean-Luc Vachiery. . (2013) Pulmonary Hypertension in Chronic Lung Diseases. Journal of the American College of usip essay, Cardiology 62 :25, D109-D116. Nazzareno Galie, Paul A. Corris, Adaani Frost, Reda E. Giardia Research Paper? Girgis, John Granton, Zhi Cheng Jing, Walter Klepetko, Michael D. McGoon, Vallerie V. McLaughlin, Ioana R. Writing? Preston, Lewis J. Rubin, Julio Sandoval, Werner Seeger, Anne Keogh. . (2013) Updated Treatment Algorithm of Pulmonary Arterial Hypertension. Research? Journal of the American College of Cardiology 62 :25, D60-D72.
Nazzareno Galie, Gerald Simonneau. . Descriptive Essay About Room? (2013) The Fifth World Symposium on Pulmonary Hypertension. Journal of the American College of Cardiology 62 :25, D1-D3. Caroline O’Connell, Dermot S. Research? O’Callaghan, Marc Humbert. . (2013) Novel Medical Therapies for Pulmonary Arterial Hypertension. Halifax? Clinics in Chest Medicine 34 :4, 867-880. Yan Wu, Dermot S. O’Callaghan, Marc Humbert. Giardia Paper? . Thesis Timeline? (2013) An Update on Medical Therapy for Pulmonary Arterial Hypertension. Current Hypertension Reports 15 :6, 614-622. Jean-Luc Vachiery, Yochai Adir, Joan Albert Barbera, Hunter Champion, John Gerard Coghlan, Vincent Cottin, Teresa De Marco, Nazzareno Galie, Stefano Ghio, J. Giardia Paper? Simon R. Gibbs, Fernando Martinez, Marc Semigran, Gerald Simonneau, Athol Wells, Werner Seeger. . (2013) Pulmonary Hypertension Due to Left Heart Diseases. Journal of the on walden or life in the woods, American College of Cardiology 62 :25, D100-D108. Ashish K Gupta, David Winchester, Carl J Pepine. . (2013) Antagonist molecules in the treatment of angina. Expert Opinion on Pharmacotherapy 14 :17, 2323-2342.
Dan-Chen Wu, Hong-Da Zhang, Zhi-Cheng Jing. . (2013) Pediatric Pulmonary Arterial Hypertension. Current Hypertension Reports 15 :6, 606-613. Daniel Conole, Lesley J. Giardia Research? Scott. . (2013) Riociguat: First Global Approval. Drugs 73 :17, 1967-1975. Markus Follmann, Nils Griebenow, Michael G. Resume Halifax Ns? Hahn, Ingo Hartung, Franz-Josef Mais, Joachim Mittendorf, Martina Schafer, Hartmut Schirok, Johannes-Peter Stasch, Friederike Stoll, Alexander Straub. Research Paper? . (2013) The Chemistry and Biology of Soluble Guanylate Cyclase Stimulators and Activators. Angewandte Chemie International Edition 52 :36, 9442-9462. Markus Follmann, Nils Griebenow, Michael G. Hahn, Ingo Hartung, Franz-Josef Mais, Joachim Mittendorf, Martina Schafer, Hartmut Schirok, Johannes-Peter Stasch, Friederike Stoll, Alexander Straub. . On Walden Or Life Woods? (2013) Chemie und Biologie der Stimulatoren und Aktivatoren der loslichen Guanylatcyclase.
Angewandte Chemie 125 :36, 9618-9639. Gregory B. Giardia Research Paper? Lim. Essays? . (2013) Hypertension: Riociguat therapy for pulmonary hypertension. Nature Reviews Cardiology 10 :10, 549-549. Archer , Stephen L. , . Giardia Research? . (2013) Riociguat for Pulmonary Hypertension — A Glass Half Full. Essays Or Life In The Woods? New England Journal of Medicine 369 :4, 386-388.
Nupur Sinha, Luis Lantigua, Masooma Niazi, Gilda Diaz-Fuentes. . (2013) An Elderly Lady with Fever of Unknown Etiology and research Severe Pulmonary Hypertension: Intravascular Lymphoma—An Elusive Diagnosis. Case Reports in thesis timeline, Medicine 2013 , 1-5.
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Adding network printers from batch or vbs script. by mpickles on Apr 16, 2013 at 4:55 UTC. Giardia? I've tried other methods found on TechNet and in the Community but I'm not having much luck with this. We've just finished creating an update to writing for beginners, our standard image and thought it might be nice to create a script for adding all of our network printers (our users don't have an ounce of 'geek' in them, to giardia research, say the least) and letting them decide on their default printer from there. Our admin won't modify the timeline GPO, and our imaging process removes printers during sysprep, so we thought we'd put a batch or a vbs on a network share that we could run this from. The printers are all shared off of our Windows 2008 R2 print server in the server room and all Domain Users have print rights to research paper, them, all clients are Windows 7 Ent x64. The latest iteration, below, doesn't appear to do anything - it just spits the first 4 lines out to on walden or life in the, the command prompt and giardia exits. What am I doing wrong here?
ON ERROR RESUME NEXT. Essay? Set wshNet = CreateObject(WScript.Network) Set wshPrn = wshNet.EnumPrinterConnections. For x = 0 To wshPrn.Count - 1 Step 2. If Left(wshPrn.Item(x+1),2) = Then wshNet.RemovePrinterConnection wshPrn.Item(x+1),True,True. wshnet.AddWindowsPrinterConnection printsrvAdmin ColorQube Your GPO Admin is a ____. Giardia Research Paper? Try the following: Dim strPrinterUNC, objNetwork. Descriptive About A Waiting? Set objNetwork = CreateObject(WScript.Network) Set objNetwork = Nothing. Please, for your sanity just use Group policy preferences. it is infinitely easier. To expand on the easier part, all you have to do is make a new group policy object. Paper? Then you goto print management on the server, right click on a printer, Deploy with Group policy. You then browse to descriptive about a waiting, the object you just created, then choose either apply to comupters or apply to users (i always choose computers) then hit ok. Giardia? Please, for timeline your sanity just use Group policy preferences. Research? it is infinitely easier. mpickles - your problem may be in usip essay this statement Our admin won't modify the GPO.
Any chance you can negotiate revisiting this problem? Your GPO Admin is a ____. Try the research paper following: Dim strPrinterUNC, objNetwork. Set objNetwork = CreateObject(WScript.Network) Set objNetwork = Nothing. Little Green Man Apr 16, 2013 at 5:11 UTC.
Yes, GPO method definitely easier if implemented correctly. But if you prefer scripts, you can do it easier with Powershell (on server 2012): Here's another Powershell method: Tutorial for ^ script: Here's another interesting one: BillKindle, that is a great find there. Or Model Body Persuasive Essay? Thank you for posting those links. Presuming you are using the scripts from research paper above here is another alternative you can choose: Make an HTML map of ns your building(s) Have pictures of each printer on the blue print Clicking on the printer gives you a drop down menu of the giardia research printer options to select from and runs the script to add that printer to the users computer.
Otherwise go with a GPO or your choice of login scripts from above. Timeline Harvard? Edited Nov 8, 2013 at paper, 3:49 UTC. French Writing For Beginners? Your GPO Admin is research paper a ____. Try the following: Dim strPrinterUNC, objNetwork. Set objNetwork = CreateObject(WScript.Network) Set objNetwork = Nothing. He claims that any GPO requests I give him won't work in our environment and sends me away. I'm drafting a letter to our boss about essays on walden getting a little more respect from him (I've been doing his job for 20 years, but am currently junior to this 25 year old). That said. running this file under Windows 7 works brilliantly. I've modified it as follows for my environment.
Thanks! Set objNetwork = CreateObject(WScript.Network) objNetwork.AddWindowsPrinterConnection ttaprintsrvAdmin ColorQube objNetwork.AddWindowsPrinterConnection ttaprintsrvCanon IR2525 objNetwork.AddWindowsPrinterConnection ttaprintsrvEast Hallway - HP LaserJet 4014 objNetwork.AddWindowsPrinterConnection ttaprintsrvEast Hallway ColorQube objNetwork.AddWindowsPrinterConnection ttaprintsrvHP Color LaserJet 2020 objNetwork.AddWindowsPrinterConnection ttaprintsrvMarketing - Xerox ColorQube 8570N objNetwork.AddWindowsPrinterConnection ttaprintsrvPhaser 6280DN-01B1D9 PCL6 objNetwork.AddWindowsPrinterConnection ttaprintsrvNorth HallWay West (Samsung ML-3312ND) objNetwork.AddWindowsPrinterConnection ttaprintsrvSouth Hallway East objNetwork.AddWindowsPrinterConnection ttaprintsrvSouth Hallway West - P4014 objNetwork.AddWindowsPrinterConnection ttaprintsrvTech - HP Color LaserJet CP2025 Set objNetwork = Nothing. Little Green Man Apr 16, 2013 at 6:44 UTC. Deploying printers is pretty easy with GPP in server 2008 R2. Giardia Paper? There are ways to use the RSAT toolkit (GPMC) on for beginners, a Windows 7 system to edit and manage GPO's still on a server 2003 functional level and maybe they are not aware of that. Research Paper? Some additional reading for essay writing for beginners you, for added ammo: Pay close attention to #3 here: That should help you in giardia research paper your research for future reference.
In my experience, someone who says GPO's won't work in our environment is usually not willing to french essay, learn Group Policy for giardia fear it might make them less busy. On Walden? I have worked for giardia research paper one of those types in the past. I'm glad you found a solution to your problem concerning printers, but I'd be concerned that your Admin either won't work with you on or model body essay, GPO solutions, or is giardia research hiding the fact that he doesn't know how. Neither is good, if true. Resume? Here is another alternative you can choose: Make an HTML map of your building(s) Have pictures of each printer on the blue print Clicking on research paper, the printer gives you a drop down menu of the printer options to select from and runs the script to add that printer to the users computer. Otherwise go with a GPO or your choice of login scripts from above. I would *love* to do this.
I might work on this over the weekend. Deploying GPO's when we have over anorexia or model body essay 300 printers is not really feasible. Research? That's a lot of or life in the woods GPO's and no we cant have every staff and paper students printing to different schools,classrooms,libraries and labs. You can try this vbs (this will install a printer to computers in a container and not by french for beginners, user): Each OU must have a unique name or the printer will be deployed to giardia research paper, any OU with that same name. 'start print vbs. Set objSysInfo = CreateObject(ADSystemInfo) If Left(arrDN(i), 3) = OU= Then. Set WshNetwork = CreateObject(WScript.Network) Set objShell = CreateObject(Wscript.Shell) Select Case UCase(strOU) Case UCase(PUT IN OU NAME HERE) Edited Apr 30, 2013 at 12:27 UTC. I know this is an older post, but I hope someone could help. I am using the following script: Sorry for all the commenting, had to do this for one of our guys :) Anyways, this script works with no issues if the printer is not already mapped and not that it is french a big deal, but when a user first logs in and the script runs they will get an error if the printer is already mapped. Does anyone happen to know how or could lead me in research the correct direction to fix this little problem. VBS is not my native language, so I'm not sure on how to go about this.
You can either (simplest, but most work required over many printers): for each printer you are going to be adding. Essay For Beginners? or you can take the much simpler route, but risky if you have a lot of manually added printers by: removing all of the network printers. Paper? A good script posted by descriptive essay about, David Gardner for Win7 from: http://community.spiceworks.com/topic/243527-delete-all-network-printers-including-local-tcp-ip-printers-vbs. Or if you want to use WMI and don't care about wiping out all network printers: Set objWMIService = GetObject(winmgmts: strComputer rootcimv2) Set colInstalledPrinters = objWMIService.ExecQuery _. (Select * from Win32_Printer Where Network = TRUE) For Each objPrinter in research colInstalledPrinters. Thanks for the Reply. I actually did do this.
However, everynow and a then I still get a script error popup. Not sure why at this point, but isn't there away to thesis timeline harvard, surpress the error messages. For the giardia end user this doesn't really matter. I'm having problem when trying to thesis timeline harvard, install a network printer from non admin account. I'm having error mesage (unknown user name or bad password) can i set my admin user and pass in this script. joshua.kohel Jan 30, 2014 at 3:09 UTC. I am working on a windows 7 roll out at multiple locations for a large healthcare provider in my area. The longest part of the entire process is hooking up the 11 printers to each machine swapped in. I want to run a script to add all printers to research, the client machine automatically so I dont have to sit there and search for each one by writing, name, double click it..wait..and cont.
Would the following work for me? Im not much into giardia, code.. -.- it annoys me. Essays Or Life Woods? I would of course change all the names to my print server and to the correct printer names..what exactly would I do after editing and giardia research Copying this text to on walden in the, turn it into giardia research paper, a runable script? lol. I have all required administrative credentials. Set objNetwork = CreateObject(WScript.Network) objNetwork.AddWindowsPrinterConnection ttaprintsrvAdmin ColorQube objNetwork.AddWindowsPrinterConnection ttaprintsrvCanon IR2525 objNetwork.AddWindowsPrinterConnection ttaprintsrvEast Hallway - HP LaserJet 4014 objNetwork.AddWindowsPrinterConnection ttaprintsrvEast Hallway ColorQube objNetwork.AddWindowsPrinterConnection ttaprintsrvHP Color LaserJet 2020 objNetwork.AddWindowsPrinterConnection ttaprintsrvMarketing - Xerox ColorQube 8570N objNetwork.AddWindowsPrinterConnection ttaprintsrvPhaser 6280DN-01B1D9 PCL6 objNetwork.AddWindowsPrinterConnection ttaprintsrvNorth HallWay West (Samsung ML-3312ND) objNetwork.AddWindowsPrinterConnection ttaprintsrvSouth Hallway East objNetwork.AddWindowsPrinterConnection ttaprintsrvSouth Hallway West - P4014 objNetwork.AddWindowsPrinterConnection ttaprintsrvTech - HP Color LaserJet CP2025 Set objNetwork = Nothing. tclevelanditc Aug 12, 2014 at essays on walden in the, 5:10 UTC. Bill Kindle wrote: Yes, GPO method definitely easier if implemented correctly. But if you prefer scripts, you can do it easier with Powershell (on server 2012): Here's another Powershell method: Tutorial for ^ script: Here's another interesting one: Every time I try this; whether using this powershell script or a vbs script I always get an error stating invalid printer name.
I do not understand I can access it just fine outside of using the script. Bill Kindle wrote: Yes, GPO method definitely easier if implemented correctly. But if you prefer scripts, you can do it easier with Powershell (on server 2012): Here's another Powershell method: Tutorial for ^ script: Here's another interesting one: Every time I try this; whether using this powershell script or a vbs script I always get an giardia research paper error stating invalid printer name. Timeline? I do not understand I can access it just fine outside of using the script. tclevelandit: This might sound ridiculous, but are you replacing the.
With your own server and giardia research printer name? GeoApps is an IT service provider. Bill Kindle wrote: Here's another Powershell method: Just Use this . all the user needs to do is type in writing the printer name and hit ok. The printer will be mapped and set as default printer. Giardia? Make sure to thesis timeline, edit the network path . should look something like myserver strPrinter. strPrinter represents the research printer name provided from the user. On Error resume next. Dim objNet, strPrinter. Set objNet = CreateObject(WScript.Network) strPrinter = InputBox(Please enter the network name of the Printer you'd like to add, Add Printer, Example: 1234myprinter) objNet.AddWindowsPrinterConnection network path strPrinter. objNet.SetDefaultPrinter network path strPrinter. If err.number = 0 Then.
Wscript.Echo strPrinter added successfully and set to default! Edited Aug 14, 2014 at 7:26 UTC. Mario Durand S. Sep 25, 2014 at essays woods, 5:29 UTC. MDSOLUTIONS is an IT service provider. Your GPO Admin is a ____. Try the following: Dim strPrinterUNC, objNetwork. Set objNetwork = CreateObject(WScript.Network) Set objNetwork = Nothing.
Thanks for your post. What about if are multiple printers? richardjones7 Jun 30, 2015 at paper, 9:18 UTC. I am part of essays on walden a team at the moment that does office consolidations and giardia research paper build outs for my company. Currently I have had great success with the following as it allows for me to read from a text file in usip essay the same folder as the vb script. This allows it to giardia paper, be on the network or ran by timeline harvard, the end users.
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Four Things to Remember Before You Leave Public Accounting. This is research, our second submission from the stable of Going Concern freelancer candidates. The following is by essays on walden Bob Loblaw. Career advice Careers Interviews Jumping ship Public Accounting Skills Author Caleb Newquist Posted on June 13, 2012 September 18, 2017 Categories Career Advice, Career Center Tags Career advice, Careers, Interviews, Jumping ship, Public Accounting, Skills. Come on Caleb, I was just joking, you’re not really a jackass. His name is Colin…I don’t know who these trolls are who keep calling him Caleb. Awe man… I was looking to giardia, get in to thesis harvard, MA. Give this man a job. Great first piece.
You’ve lived up to giardia paper, the Bob Loblaw legend. Given #1 “You don’t have skills”, why should someone stay until manager, as advised by “survey’s of past alumn”, rather than leaving after a few busy seasons? I’m glad you asked (seriously)…. Obviously the piece is usip essay, filled with an overdose of cynicism, but it is misleading to giardia, say that you don’t develop any skills in resume halifax public. I think my point here is that things in industry are so completely different from public, that you should be wide open and be ready for anything. In the past year, I’d say I spend 15% of my job on giardia research paper “accounting” and the other 85% on thesis timeline harvard anything ranging from dealing with banks, business development, and a host of other things. Just like any job, most of what you learn is on the job. Paper! I actually hire only usip essay straight out of public, and I know a lot of my buddies do too. Giardia Research Paper! The reason is or model persuasive essay, that they have developed a diverse skillset which makes them able to research, adjust and learn quickly. I agree that you should stay until manager. Protip: don’t engage every comment.
It makes you look desperate (you can trust me on this). Writing! Go have a beer and research let ’em fight it out amongst themselves. Of course I’m desperate, I’m applying for thesis harvard, a non-paying job writing about giardia paper accounting. So sad. If it makes you feel better, I’m drinking a beer right now at my desk.
In fact, I’m about 90% loaded as I’m typing this. I’m pretty sure “Bobloblaw” is full of shit. He talks a big game like a lot of audit partners I know, but when the rubber meets the road, he hides under the desk. Resume Halifax Ns! I’m even willing to bet that Bob isn’t Bob’s real name. I could be wrong though. Giardia Paper! I’m sure its not uncommon for the controller of a company to be “90% loaded” while at thesis, work and brag about it on the fucking internet…even though he doesn’t actually have the balls to get loaded at work. Protip: Get off your high horse and get back in touch with your reader base. Then maybe people will start listening to paper, you again.
*munches popcorn while watching the clowns dance* You suggest staying until manager, but what are reasonable options for an S1 in in the a mid-tier or Big 4 firm leaving? Because a manager in paper public won’t ACTUALLY be qualified to run your company, wouldn’t it often make more sense to just make a lateral switch at usip essay, a higher salary as an giardia paper S1 and get 3 years of timeline harvard private experience? A year ago I would have said no way. But I have seen some guys leave at S1 that have done really well. I think the giardia, biggest mistakes are folks that leave to get stuck in on walden or life in the woods the big public company machine. I think the best option is private company with good prospects because you grow with the company and you get a diverse experience, and best case, you go public and research get the big payday. But if you switch over to some kind of senior analyst job at thesis timeline harvard, Exxon or some other super-corporation, you’re really doing yourself a disservice. That makes sense, thanks. Is there any significant reason to leave at S2 or S3 instead?
It seems like if you’re going to giardia research paper, stick it out that far, might as well make it to Manager. Well done. I think I might have actually learned something. I look forward to your next piece. By jumping between firms, are there any acceptable reasons to do so? i.e. small to big, big to regional, small to resume ns, regional, differing indutries? Yes, I am stalking the giardia research paper, comments. Sue me.
Again, toning down the cynicism a bit, I would make a couple of qualifications. Small to big is absolutely acceptable. French Writing For Beginners! i.e. – you didn’t get a Big 4 offer, you get some experience, and you move up. That I think is very OK. Big to paper, small I’d question very hard. Essays On Walden Woods! A few exceptions – Someone who isn’t going to make partner in big 4, or a higher level person burnt out with Big 4 politics.
I’ve seen a half dozen people at first year manager or below jump, and giardia paper they are out of public a year or two later with no exceptions. So I would generally say that these folks are the tough to please type. Big 4 to a waiting, Big 4 is absolutely and in every way illogical. Like I said, everyone I knew that did it was a shithead. I jumped Big 4 to Big 4 as a senior (and was not about to get fired). My last firm wouldn’t put me on larger clients until I had one foot out the door. I wasn’t ready to leave public accounting though.
I’m happy with the switch- I have a better client base, faster promotion track, and research higher salary. Anorexia Body Persuasive Essay! I’m still not planning on leaving until I have at least a year of manager experience under my belt (and that was the plan before the switch). I guess you could call it high maintenance, but I don’t think so #128578; You are very polite, I do not think you are a shithead. I quickly (year 2) jumped from embarrassingly small to respectably small for more opportunity. My second firm went into the shitter due to various reasons and I jumped to a larger local firm where I saw an opportunity for partnership.
Grant it, I had been trying to giardia, get out of public since year 5 but staying in halifax ns public and research switching firms paid off for the Horney One. Only kidding of french writing for beginners course, that was just the research, most insulting thing I could think of for someone’s first foray into public writing. Well written piece. You mean, because, “Fuck You” was already taken? Lol, nice work. Resume Halifax Ns! I know a lot of B4 Managers and Sr. Managers that need to read this for an ego check. Typical former audit senior who was never going to giardia paper, make partner. You’re going to become one of those worthless Sr Mgrs Big4Vet talks about, if you haven’t become one already.
So is essays on walden or life, my career doomed if I have only giardia research paper worked in private industry and have no experience in public? Any tips on how to apply for food stamps? Just until you’re early 50’s when you’ll be laid off and replaced by a 30 year old who they can pay 40-50% less. So… what if someone jumped from Public to Public because they moved? Are they considered a shithead? My wife did that when we moved overseas and she is definitely not a shithead, so no. I know some people who have jumped from essay writing for beginners Big 4 to Big 4 in order to work in a line of research paper service their first Big 4 employer did not offer. Are they shitheads? They are definitely shitheads.
Have you ever noticed that when studying for a multiple choice test the or model, answers with the giardia paper, words, “never, always, or all.,” are never correct? Your rush to the conclusion that “They’re all shitheads,” is no different than someone saying, “All women can’t drive,” or “All black people are good at basketball.” These are all generalizations, and generalizations result when people don’t want to think. It is pretty scary that you are allowed to hire people for your company, as I’m sure they have missed out on french essay writing some very qualified candidates due to your inability to think beyond your conventional wisdom, which I am sure has been developed through a strong desire of intellectual curiosity. I cannot argue with your perspective that your friends who jumped Big 4 to Big 4, are ‘shitheads,’ those are your words and view, which you are entitled to. However, what I do wonder is whether, those ‘shithead’ friends are the kind of people you choose to hang out with or the research, type that are attracted to you.
I’m going with the ladder…… Going Concern can do much better. the ladder? what are you trying to climb? Not all black people are good at basketball but 78% of NBA players are black. That means 78% of usip essay Big 4 jumpers are shitheads.
Why not talk about whit people and giardia hockey? How about an essay explanation? Maybe provide at least some detail on one of your, apparently four, examples. If someone starts in one practice and does not enjoy it nearly as much as they had imagined it seems that a switch would make sense. Through working in the first practice, and giardia frankly for most people their first real full-time job, a candidate is bound to learn things about themselves and anorexia essay work in general. If after a few years they learn of another position that more suits their interests and ‘skills’ then why would the switch classify them as a shithead? Fair question…. OK, first the tone of my article is wildly cynical, and giardia generally assholish. Just trying stuff out and probably got a little crazy. Descriptive A Waiting! To be clear, I don’t honestly think anyone is research paper, a shithead for essays on walden woods, jumping firms. After spending a day frolicking through the reader feedback, I could write a whole article with clarifying points, but I think that might give Big4Vet an aneurysm.
Not to giardia, mention, I’m setting myself up as a slam dunk candidate for essays or life, an Adrienne pocket veto. So, 3 of the 4 are the paper, exact same story. Very talented people, very bright, and frankly I thought they did great work. However, they also came in with a sense of entitlement from day one like they were more valuable than their peers. They wanted to be early promoted, they wanted to descriptive a waiting, go to giardia paper, audit committee meetings as a senior, and ns they generally wanted things that frankly you just have to wait on. So they got impatient and jumped ship. Giardia! I lost track of 2 of the 3, but I received the third ones resume when I started looking to on walden, fill this position a year after he/she switched firms. I certainly wish all 4 of them the giardia research paper, best, but if I’m reviewing resumes, I would question very hard why someone switched firms for the exact same role at another firm. Changing service lines, size of firm, etc, I can understand, but just switching from senior auditor to senior auditor is a red flag to french essay for beginners, me.
“Crazy” is giardia research, a veracious adjective. I agree with you about switching for or model body essay, the same position, with maybe one or two exceptions. The switch would need to be explained anyway so I guess the exceptions are a moot point for resumes. Have you seen people switch because they were doing a terrible job at their old firm? Or did you see people switch firms for the same position because they wanted to paper, move to/from a particular client or industry? What are your thoughts on descriptive this? When I was in the UK and Africa, people switched firms all the time. Giardia Research! Totally different culture and the movement between firms was fairly fluid, so I guess I was understating how many I’ve seen. Timeline Harvard! Referring to the US though, there usually was a negative reason behind it.
The 4th person I didn’t mention was one of giardia those that was doing a terrible job and switched. In fact, I have no idea how he/she got hired at the other firm. I’m in Texas, so the industry groups are “oil and gas” and “other” and its a fairly even split between the firms. So no, I haven’t seen anyone switch just for industry. Perhaps in a market where there is a huge disparity in industries by firm I could see it. But honestly, making such a large move for industry below the level of manager doesn’t seem to french essay writing for beginners, make a lot of sense to me.
I came back from South Africa as a Manager 3 having done nothing but mining and telecom for the previous three years and immediately jumped into oil and gas, which has been very good to me. I’ve seen other examples where people worked in the airline industry their whole careers and then the airline mergers hosed them and they ended up with a whole new industry.So making a huge career change like that so early in your career just to end up in giardia paper an industry that may go away 5 years later doesn’t seem to make a heck of french essay writing for beginners a lot of sense. Again, different geography may completely change thing. i.e. Giardia Paper! – in a huge market like NYC or Chicago, there may be a whole different dynamic. I agree, and I am one of the shitheads. Not sure why everyone’s getting on usip essay your case about this, but I read your big 4 whore section and paper had to or model body persuasive, say, uh, yep, that’s me. I switched to giardia, another Big 4 and – SURPRISE! – same stuff I didn’t like at the first is stuff I don’t like at the second, even though the current guys talked it up like things would be different. Usip Essay! So yes, by definition I think I acted like a shithead.
So I am now having to submit a resume that shows me going to another Big 4 for about a year and deciding oops, never mind. That’s going to be fun to talk about in interviews, so people you should think about that. The cynicism adds some humor, but how about some advice then for younger crowd just getting started in accounting? Your article makes me wanna run for the mountains and giardia research be a ski instructor or something. Surely accounting isn’t that bad.
How about some good exit options? If there is such a thing….. This guy is clueless. I have seen people who have gone from auditing to IB MA work, consulting, operations, etc. You just have be willing to try new things and meet new people, and in the woods from there talk to giardia research, them and see how they have gone from timeline point A to research paper, point B. Based on how this article sounds, I don’t think the author has done this very much in the past. I love the younger crowd.
As Matthew Mcconaughey once said, I keep getting older and they keep stayin’ the or model persuasive, same age. Also they are motivated and are good accountants. I appreciate your question youngblood, and I have written a SEPARATE article (with pictures) that is nothing BUT advice to the younger crowd. If I get rejected, get my e-mail from Colin or Caleb or whatever and I’ll send it to you. It is money. You guys love to giardia, whine and resume complain.
I thought it was a great article and hope that Bobloblaw sticks around. 75% of research paper goingconcern is already geared toward the on walden woods, “younger crowd.” This website would be more useful with a few more articles written with the 5 – 10 year crowd in mind and giardia research paper fewer questions from thesis timeline harvard interns and interns-to-be. The problem with that is that anyone above the “intern” or “intern-to-be” level isn’t going to pound out an advice email looking for our help and giardia research will already know how to make the jump to where they want to be because they’ve been around long enough to figure it out on their own. Essays Or Life Woods! It’s either AccountingWEB or this, take your pick. I do agree with you though, I’d love to figure out research a way for us to expand coverage for the 30 and usip essay above crowd but since most of giardia that group (Colin and myself are such) is independent, jaded and indifferent, it’s difficult to body, appeal to such a lackluster group of people. Omit the giardia research, first two paragraphs of self-indulgent claptrap and trim the resume, rest by research paper half. In The Woods! I’m curious – which parts caused you to “make youself laugh”? Calling Colin a jackass after you’ve earned your stripes might be funny. Doing it in research paper your first piece just sounds presumptuous. I bet you’re british, because nobody thought I was funny when i was living there, and because you said claptrap.
You have to trust me, in America, I’m hilarious. Best of luck in thesis timeline harvard the Eurocup. Tough group you’re in. I said claptrap because it was claptrap, not because I’m British (I’m not). You need to have your spellchecker checked because you misspelled “delusional” as “hilarious” and research paper it didn’t catch it. That said, you had the descriptive essay about a waiting, gumption to write something, which is research, more that can be said for me. So tally-ho. I never thought I’d say this, but I fucking miss Daniel Braddock and Joe Kristan. Hey Colin, can you get at least one of those guys back and get rid of this Bob Blowhard or whatever his name is?
There was not one piece of accurate or intellectually honest content in the above rant. All I got from this piece is that Bob appears to have a serious inferiority complex. Or Model Body! Now on to my criticism of the actual content… 1. Of course people leaving public accounting for private industry have skills. If they didn’t have some fucking marketable skills, no one would be hiring them. If they don’t have fucking skills, then what is Bob doing wasting his precious time interviewing them??
In addition to learning how to research, deal with assholes (like Bob), people in public accounting develop a ton of technical accounting knowledge and skills, not to resume halifax ns, mention a solid work ethic and an extraordinary ability to figure shit out for themselves when their supervisor is an incompetent fuckwad. Research! Speaking as someone who works in descriptive about a waiting private industry and would give my left nut if my company would open its cheap ass wallet to giardia research paper, hire a Big 4 staff, I couldn’t possibly disagree more with what Bob said in resume his opening point. 2. I’m glad Bob has been able to achieve expert status on the topic of people leaving one firm for research, another firm. Thesis Timeline Harvard! After all, he’s known FOUR people who have done this. That’s like two squared! 3. Yes, you are special. This is fucking America you motherfucking communist.
We are all special. Have you never watched the giardia, Jerry Lewis telethon?? It’s fucking must see TV. But seriously, is it possible that people brag all sorts of french for beginners good things about themselves because that’s what you’re supposed to do in an interview, or perhaps because they ARE excited about the job and want to sell themselves for it? Aw, never mind. That was too serious a thought…this article is not worthy of giardia paper such discussion. 4. If I had a nickel for every person I knew of that went from essay for beginners accounting to giardia paper, some other area of a company’s business (e.g. Writing! MA, finance, operations), I would pay Bob $1 million to never write another fucking article on this site. B4V – I appreciate your spirited views. Giardia Research Paper! (1) Caleb made the titles and I think “you have no skills” is a bit harsh. Descriptive A Waiting Room! (2) I did clarify in research one of the comments above that I hire exclusively out of Big 4. Halifax! I’m down with the work ethic and figuring shit out, but nobody is goign to make it past middle management with the “technical skills”. (3) I assure you that Big 4 to Big 4 is a shithead move. (4) By “other area of a company’s business”, I’m referring to a meaninful management position with some prospect to advance, not “revenue accountant”, “due diligence bitch” or “analyst”. Thanks again!
(1) The “You have no skills” was the most intelligent (and clever) portion of that comment. You shouldn’t have given Colin credit for it. (2) Yeah, I can see what you’re saying. Why the fuck would a company want to giardia paper, hire or promote someone who has technical skills? That’s so fucking boring.
What a company really needs are more incompetent bullshit artists. When I look at the CFO of my company, I just think “Well, you may make $500k a year and have millions in stock options, but I wonder if you have any technical skills?” (3) Thanks for elaborating with logical and articulate reasons for why it is a shithead move, whatever that means. (4) So was I. Usip Essay! Does CFO count? Almost every fucking CFO I know or have heard of started out at research paper, a Big 4 firm. Your blind fury is harvard, riveting. Giardia! (2) People are CFOs because they are engaging, they can talk to a board, they have a good sized network, and they have executive intangibles. Nobody gives a shit if their CFO is up to or model, date on giardia paper the results of the on walden woods, latest SEC speech about leasing. Giardia! If its relevant to the company, said CFO will get a 10 minute update from his CAO or controller before the board meeting. (3) You just have to trust me on this one (4) I would say that CFO wouldn’t be jumping to another area of the on walden, company’s business. Obviously many CFOs come straight out of research public.
I’m talking about people with 3-5 years of experience wanting to run an MA deal on day 1. What you’re saying doesn’t make any sense, and you seem to be qualifying your earlier comments. (2) What are these executive intangibles you refer to about, and where do they come from? In your mind, is technical skills the giardia research paper, same thing as listening to the latest SEC speech about leasing? And if the new leasing standard has a major impact on your company’s operations, wouldn’t you want to anorexia body persuasive essay, be up-to-date on research that if you were the CFO? (not that I’m suggesting that the CFO has any obligation or duty to understand major issues which may be impacting his business…after all, this is essay about room, America). As for being engaging, having the ability to research paper, talk to french essay writing for beginners, a board and having a good sized network, you make it sound like lots of people have what it takes to be a CFO. Do you really have any idea of giardia research what it takes?
Are you aware of all the other responsibilities that goes along with being a CFO, or did you miss all those because you’re “90% wasted” at work? (3) Ok, I’ll trust you. Very good writing there, dude. (4) Here is where you’re qualifying your earlier comments. Most people don’t go straight from anorexia persuasive essay public to CFO. They work their way up. Many CFOs started in public though, a fact which seems to undermine your argument.
As for giardia paper, moving to other areas of the business, all sorts of french people start off in accounting and then move into something else. You’ll have to trust me on this one. By the way, I’m not saying you’re terrible at giardia research paper, this blogging thing just because I’m a dick. I really honestly think you’re terrible at thesis timeline, it. You’re may be a good controller and paper you should stick with that. I really hope Colin and Adrienne don’t fuck up this website even more by adding you to the writing roster. Sorry to be harsh, but I’m just being honest. Your first blog post was really terrible. This is why B4 sucks ass… at my boutique firm I already do MA, review FS, have my own clients, bill my own clients, no non compete agreement if I leave, make $100k before bonuses, and this is or model persuasive, my 4th tax season. Unfortunately these commetns only let you reply like 6 deep so just know I’m responding to giardia research, whatever your last post is…. Honestly, I feel like I’m arguing with my 90 year old grandmother about why its ok to use credit cards (I was on the “they are good” side).
So as much fun as this is, I’m going to leave it with you like I leave it with granny and let you just be confused and angry like granny always is… First, dude you need to open a Disqus account. You need to go big time if you’re going to be a writer for about, GC. Second, I actually don’t think you’re a douchebag or nearly as big an asshole as you tried to make yourself out to be in your blog post. You and I might even get along fine in real life. I just thought your post was a bunch of giardia bullshit and over french essay for beginners, the top. It seemed like it was more about giardia paper framing yourself as a badass than trying to provide advice to the GC faithful. You can probably do better given your education and experience. And I think GC should do better.
Furthermore, I don’t even think you really believe most of the bullshit you spewed in your post. I don’t think you get to be controller of a decent sized company with an attitude like that. awwwwwwwww, i feel like we should hug now. However, you should make no mistake… I am absolutely an asshole. I agree, I probably went a little Maddox on essay about that one calling people shitheads and so forth, but in principle, I do stand by my opinions/advice. If I were to restate in a kinder and gentler manner it would be (1) You will be doing things completely differently when you switch to industry. Many if not most of your skillset will not translate. i.e. – unless you are in a technical accounting role, you will not be analyzing accounting on a regular basis. However, there is research paper, a good reason why many hire straight out of big 4, which is adaptability, flexibility, intelligence etc. You will definitely learn on usip essay the job, but don’t assume you’re going to giardia research paper, walk in and change the world. (2) Firm hopping – In my experience, this has shown a lack of commitment if done before the level of second year manager. Of course I am one person, and I have only resume halifax worked in three cities (3) The you’re not special part – It’s a very competitive environment.
I assumed coming out of public that I was hot shit and I would have people banging down my door to give me a job. What I neglected to note is that public accounting is the only environment that mass hires accountants. i.e. – there are a lot of talented individuals competing for giardia paper, the best jobs. So when you go into essay an interview, don’t spend the whole time grilling the guy and giardia finding out usip essay how its going to work out for you. It’s not a foregone conclusion you will get hired and you need to put forth some effort. (4) You’re an accountant – Just like in campus recruiting, everyone wants to do something special… transaction support, forensics, etc, etc. However, your experience is accounting and you’ll likely have to research paper, hire on as an accountant (generally speaking). Given the choice, most companies would rather hire someone with MA and Big 4 experience rather than just straight big 4. So you get your accounting job (i.e. – controller) and then once you have your foot in the door, you start working towards your interest…. ops, treasury, MA, etc. I personally want to be a trader so I can leave at 3 every day and get a 7 figure bonus. So that’s kind of the or model persuasive, cleansed version, but that would have been VERRRRRRRRRRY boring. I feel sleepy just writing it.
Maybe it would have been boring (I don’t think so, and many others who are looking for advice here probably wouldn’t think so either), but you could probably think of a way to paper, write it in usip essay a more interesting way. At least you’d be genuine and honest. Or if you can’t think of a better way to research, say it, then write about something else. I think great writers are creative AND honest, and it helps to be funny too. Bob must have gotten something right if he got B4V’s panties in a bunch to this extent. Yes, because that’s the mark of good writing on this site. If B4V doesn’t like it, then it must be good writing. All I’m saying is that while GC isn’t a totally serious place, there is a lot of harvard thoughtful commentary on here by Colin and JDA, and that commentary isn’t usually filled with insincere bloviating and grandiose bullshit like Bob spewed above (although it was complete bullshit and lacked originality, Bob’s story about making a recruit pay for giardia, his own lunch was HILARIOUS though). Look, at ns, the end of the day, its Colin’s website and can do whatever he wants. Research Paper! If he wants to fuck it all up by hiring Bob, that’s his choice.
I won’t lose any sleep over a waiting room, it. Based on giardia your comments so far, you seem to essay writing for beginners, have already lost a great deal of sleep over it. They are obviously during the evening. Paper! Maybe you go to bed before the sun sets, or shortly thereafter, but most people do not. i think Big4Veteran is jealous he didn’t get the position and that bob is out-smarting him. go home big4veteran. or go slit your wrists, seems like you’ve been wanting to usip essay, do it for a while. I think B4V had made a lot of valid points, more than Bob. What I find interesting is how both of them have argued the post to death. Giardia Research! At the end of the or model persuasive, day I think we need to leave it to the readers to decide if a piece of writing is good or bad. Giardia! In this case, i totally disagree with contents of the article and about a waiting room agree with posters such as B4V and others who refuted the points made. Research Paper! On the other hand, the writer has managed to ruffle a few feathers and get some good discussion going here which is descriptive essay, never a bad thing. As long as someone writes something and giardia research paper can back their opinion I think thats fine.
I would also urge B4V to start writing either here or on a new blog. I find your comments interesting and it is a shame a lot of them get buried in the comment boxes all the time. You have a lot of share and I find that if you actually wrote full length articles, I would be the first to read them. Hope you do not construe this as a negative comment, I honestly enjoy your posts even thought i disagree with them sometimes. All the best Bob, hope you keep writing even if the GC gig does not pan out. B4V posing as GCreader?
Hmm… I can assure you that I am not B4V. I just made an honest comment and if people want to think of usip essay consipiracy theories it is giardia research, not my problem. Like I said, I disagree a lot with B4V and he does come across as an arrogant prick sometimes, but the reason I even visit this site is to resume halifax, read people’s opinions and giardia research paper he is one poster who has a lot of that. Resume Ns! Same with the giardia paper, poster of this article, I think the descriptive a waiting, article was fine, it was someones opinion and here we are commenting about it.
That is the whole point of GC. Seeing as you support bobloblaw and post in research paper a similar fashion I will use his, and consequently your, approach to responding: You are an idiot. Note that no further explanations are needed or required to support this statement because I am either too lazy or stupid to have thought through it on my own, nor have I taken the time to actually read, comprehend, and understand what was said to support my ludicrous statement. BlahblahBlah – disagree with plenty you have to say but I like to see the pot stirred and read 50 comments from french writing this crowd. Here’s a ProTip courtesy of my grandfather “Don’t get into a pissing match with a skunk” (or an argument here with B4V). And B4V I do like and giardia paper agree with lots you have to say (god knows there is french essay for beginners, lots) but do you really have to be so obnoxious about it? I’d read longer pieces by you too, gladly, if I wasn’t invited to giardia research paper, have coitus with myself in the process. Or in fewer words: fapfapfapfapfapfapfap. There may be 50 comments on timeline harvard this post, but at least half of them are by Bob (and probaby 1/3 are by giardia paper me).
I don’t think you’re an asshole B4V, sometimes a little dickish but you don’t go overboard. You are the best writer on thesis this page by research far. I thought the usip essay, piece was just fine. Bob loblaw you sound sooooo dreamy. I definitely am Scorpio, I’m a svelt 300 pounds, I always dress in fashionably dark colors for the slimming effect and to hide coffee stains, and I almost always get my socks to match. I’ve been described as a mix between Robert Pattinson and Chris Farley, but less pale. I give this guy a B for his first article. Probably would have been more of a B+ but he just comes across as an angry, divorced bastard in the comments.
Agreed that I have gotten far past carried away in giardia paper the comments, but I haven’t had this much fun since I accidently doubled my Adderrall dose before a board meeting last month. Most of the accounting morons who read GC do need someone with a strong pimp hand to tell them that they are on the whole, worthless. Don’t worry, most of body them will quit reading your pieces unless you throw the tags “CPA Scores” or “Prometric” in giardia research paper your article heading. You have to anorexia or model body essay, applaud anyone who gets this many comments – subtract 30% of giardia research them which were his own responses to comments and essays or life woods you still have a great amount of discussion. Subtract another 30% for giardia, my comments, and probably another 20% for comments completely unrelated to the article. Einhorn is Finkle! Finkle is Einhorn! Funniest article I’ve read in thesis a long time. Giardia! Keep it up! Give this man an (unpaid) job!
By pissing people off, Bob will keep people coming back (especially to see the shit-throwing contest between him and B4V). People coming from public accounting certainly have a certain amount of technical expertise, but what’s most important are the unobservable characteristics that a Big 4 firm on a resume signals. “The moment I sense that my interviewee is on walden or life, trying to figure. out what I can do for him, or giving me any indication of research paper indifference, I. will start ordering double scotches until I black out. Harvard! Then I will make. the kid pay for his lunch.” We cannot pass up this golden nugget of amazing lines from this article. Bob, you nailed it! I recently jumped ship from a Big 4 firm to an industry job in oil gas. Research Paper! The first thing I noticed during my interview is french essay writing, that the research paper, only way I was getting any credit for spending a couple years at a Big 4 firm is if most of my clients had been oil and gas companies and if I had moderate to expert knowledge of descriptive about room SAP. Unfortunately, I had neither.
Because they were in desperate need of more employees, I was hired as an associate accountant (lowest level on the totem pole). Thankfully, my frustration only lasted approximately 30 seconds because my starting salary was significantly higher than what I had been paid in public (and I wasn’t even a CPA yet). I recently started a website dedicated to providing accurate information about the CPA exam. My latest post covers the giardia research, pros and cons of public vs. industry. I’d love your input on my -link redacted- As you can see, I know much more about financial reporting than I do about HTML. Good grief. Link removed, we don’t allow that around here. If you want his input, you can link to usip essay, your email address so he can reach out. Okay, my apologies.
This site is the greatest. Thanks for all the giardia research paper, great articles! Hire this guy. He gets it both in tone and essay experience. Bob’s the winner. I still dont understand whats wrong with changing from big4 to big4..
Anyone please elaborate. Please tell me where you work so I can be sure to never apply. Giardia! You sound like an arrogant ass. I think there’s a going concern for this author as a writer. Hey Bob, I came across your article while searching for ways to french for beginners, get into research the big four. Do you have any advice or recommendations for an internal auditor with no external auditing experience on how to get a job at the big four? I passed the CPA exam, if that means anything. Thanks. Bobbi, only idiots will have no skills after years in usip essay public.
Sorry, you interview only those! There are people who get some skills and want to giardia paper, leave because of the family. And then there are those who have skills and will probably stay in the firm and make a partner or make a CFO. This seems like something someone who couldn’t get into the big four would say. No wonder you’re bored blogging.